Endocrine Abstracts

Introduction: Celiac disease (CD) is a common condition in children with type 1 diabetes (T1D). This condition is often asymptomatic and predisposes to severe complications of diabetes. The aim of this work was to study the clinical, biological, and evolutionary features of CD in diabetic children compared to a control group of non-celiac diabetic children.Patients and methods: Retrospective study of a cohort of 10 T1D children with CD compared to a cont...

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease that occurs mainly in childhood. In its multifocal form, the central nervous system may be affected, but rarely as the primary site of the disease. The prevalence of central diabetes insipidus (CDI) ranges from 10% to 50% and in most cases is established after the diagnosis of LCH. We report 2 cases of CDI that revealed a LCH.Observations: Case 1: A one-year old male patient was admitted...

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease characterized by non-specific granulomatous deposits in many tissues. The hypothalamic-pituitary region is infiltrated in 5 to 50% of patients with LCH but most often in those with the multifocal form. Diabetes insipidus (DI), the most common hormonal abnormality, occurs in 15–50% of patients. Anterior pituitary deficiency occurs only in 5 to 20% of patients. We report the case of a patient with LCH who h...

Introduction: Short stature is a common manifestation of Noonan Syndrome (NS) that affects up to 70% of patients with this syndrome. We present 2 observations of NS associated with growth hormone (GH) deficiency.Observations: Case 1: A 7-year-old female patient was admitted for a growth delay (height at −4 SD and weight at -1 SD). On examination, she had a dysmorphic syndrome suggestive of NS: triangular face, hypertelorism, low-implanted ears, a w...

Introduction: Known to be ‘male Turner syndrome’, Noonan syndrome (NS) classically associates short stature, facial dysmorphism, and congenital heart disease. It is an autosomal dominant disease with an incidence of 1: 1,000 to 1: 2,500. We report 3 observations of NS.Observations: Case 1: A 7-year-old female patient was admitted for a growth delay. On examination, she had a dysmorphic syndrome suggestive of NS: facial dysmorphism with triangul...

Introduction: Many problems hinder the diagnostic and therapeutic approach of growth hormone deficiency (GHD) in developing countries. The lack of early diagnosis and adequate treatment have adverse consequences, especially the small final height with the resulting psychological impact. Our study examined 40 cases of GHD who received treatment by recombinant human Growth Hormone (rhGH).Patients and methods: This is a retrospective longitudinal study of 4...

Introduction: GH deficiency (GHD) is a rare etiology of late growth. Its exact prevalence is unknown in emerging countries such as Tunisia. Despite a very suggestive clinical presentation, the diagnosis of GHD remains difficult and relatively late in some patients. Our study examined 40 cases of GHD in the Sahel region of Tunisia.Patients and methods: This is a retrospective longitudinal study of 40 cases of GHD collected in the pediatric department of M...